Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) ( As we mentioned earlier, GPX7 does not contain domains bound to GSH, so it cannot participate in redox reactions with GSH as a substrate like other GPX family members
Botelho, I.M.B., Moura, N.A., Silva, C.A., Tambascia, M.A., Alegre, S.M., Zantut-Wittmann, D.E
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doi: 10.1007/s11033-023-09199-2 36 MedinasD
For instance, biotin-cysteamine-Cypate conjugates undergo GSH-triggered hydrolysis, leading to aggregation that enhances both imaging signals and photothermal efficacy [83]
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