semaglutide and tirzepatide cost found to be more cost-effective than in patients with knee osteoarthritis, obesity GLP-1 (Semaglutide & Tirzepatide) Weight

A study by Newsome et al., designed to evaluate semaglutide as a potential treatment for Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH), showed a dose dependent decrease in ALT levels, with maximal reductions occurring around week 28 and remaining stable thereafter [38]

For adults, Wegovys dose starts at 0.25 milligram per week and can progress up to 2.4 milligrams

Also, talk with your patients about how they can stay safe

Sources: Mounjaro Uses, How it Works and Side Effects (2025) Diabetes UK (Accessed 6 October 2025) Tirzepatide (2025) NICE (Accessed 6 October 2025) Tirzepatide for managing overweight and obesity (2025) NICE (Accessed 6 October 2025) Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (2025) New England Journal of Medicine (Accessed 6 October 2025)

The medication that addresses the engine itself is metformin, or in 2026, a GLP-1 receptor agonist

doi: 10.3389/fonc.2023.1089115 72 XieCZhuJJiangYChenJWangXGengSet al