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Other research has been limited, mixed, or difficult to apply to modern clinical practice

Discordant research findings may be attributed to varied research methodologies and characteristics of the control group, including differences in age, sex, and socioeconomic factors

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Participants in whom Parkinsons disease was diagnosed less than 3 years earlier, who were receiving a stable dose of medications to treat symptoms, and who did not have motor complications were randomly assigned in a 1:1 ratio to daily subcutaneous lixisenatide or placebo for 12 months, followed by a 2-month washout period

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