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HOW ARE PATIENTS AFFECTED BY DRUG SHORTAGES

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Exposure to UV light and atmospheric oxygen generates reactive oxidative species that convert tryptophan's indole ring into oxidized products (kynurenine pathway derivatives and others)

(PubMed) Przybelski RJ, Binkley NC

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1