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6 Inhibiting the DPP-4 enzyme enhances the action of GLP-1 by prolonging the half-life and increasing circulating GLP-1

Semaglutide is also linked to digestive discomfort, though individual tolerance can vary significantly between patients

For people in remission, these effects may mimic or overlap with ulcerative colitis symptoms, making it harder to tell whether a flare-up is happening