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People with very fair skin often carry MC1R gene variants (like R151C or R160W) that produce a receptor less responsive to melanocortin signaling
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Combine this with the fact that most people on SNRI medication are more severely depressed, and alcohol doesnt mix with SNRIs
Montrose-Rafizadeh et al., 1994
Some protocols combine all four peptides for comprehensive recovery support, though this increases both complexity and cost
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