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3 Department of Surgery Innovation Center, Mayo Clinic, Rochester, MN, USA

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Study ClinicalTrials.gov NCT01280344 Type Phase II Subjects Postoperative ileus Key Finding Program discontinued after lack of efficacy signal for the POI endpoint

A subsequent study to understand the mechanism of action of DHS was carried out employing CHO cells as a cellular model (Table 2) [65]

Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)