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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

10.1016/j.freeradbiomed.2012.07.021 Free Radic

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Notably, AMPK inhibition abolishes these benefits, confirming that -PAEs protective effects are AMPK-dependent ( Table 1 Multi-targeted mechanisms of hepatoprotection

Therapeutic strategies with enhanced accumulation of therapeutic targeted renal tubular cells are urgently needed in the clinic

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