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15 In addition, postoperative alterations in the pharmacokinetics of medications have been described and can be attributed to a variety of mechanisms

Pregnancy Teratogenic Effects: Pregnancy Category C: Animal reproduction studies have not been conducted with hydroxocobalamin

Initial Treatment Dosages for Severe Deficiency Adults with severe vitamin B12 deficiency often start with higher doses

In most clinical trials, Tonmya demonstrated an acceptable safety profile, although " one study " did show an unprecedented increase in side effects and discontinuations

According to various studies, the body seems to need only about 0.5 1 g vitamin B12 per day for optimal function