In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%)
HarchPGAndrewsSRFogartyEFAmenDPezzulloJCLucariniJet al
But many patients on sublingual formulations report significant appetite suppression and meaningful weight loss
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The difference is that MOTS-c gets there through metabolic signaling and gene expression while NAD+ gets there through substrate supply and repair enzyme activation
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