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rather, it exemplifies how endogenous peptide systems with pleiotropic signaling can be rendered clinically tractable through advances in peptide stabilization, pharmacokinetics, receptor bias, and dosing strategies
formulation, optimization, characterization, ex vivo skin deposition/permeation, and anti-melanoma evaluation
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These receptors are designed to detect potential harm, such as pressure, temperature changes, or chemical irritants
Figure 1 A metabolite set enrichment analysis made from the 31 metabolites significantly modulated by MTX confirmed the major impact of the drug on glycine and serine metabolism, the urea cycle, alanine metabolism, and arginine and proline metabolism ( Figure 1B )
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