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Mechanism and duration of action : Prescription semaglutide provides continuous GLP-1 receptor activation throughout the week due to its extended half-life and high receptor binding affinity

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Primarily, Mounjaro is used for blood sugar control in type 2 diabetes patients, while Zepbound is FDA-approved for promoting weight loss and weight-related complications like moderate to severe obstructive sleep apnea

In db/db mice, ameliorating lysosomal damage by melatonin restores autophagic flux in TECs, and consequently slows the development of DKD (69)

As an obesity medicine physician scientist who regularly cares for patients with complex inflammatory conditions, this study reinforces what many of us have suspected clinically that the benefits of GLP-1 receptor agonists extend well beyond blood sugar control and weight loss and may fundamentally alter the disease trajectory for some of our highest-risk patients. Stanford, who was not involved in this research, is an obesity medicine physician scientist, educator and policy maker at Massachusetts General Hospital and Harvard Medical School, both in Boston

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