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List of the abbreviations PRP: Platelet-Rich Plasma MRI: Magnetic Resonance Imaging ACL: Anterior Cruciate Ligament NRS: Numerical Rating Scale KOOS: Knee Injury and Osteoarthritis Outcome Score TLKSS: Tegner Lysholm Knee Scoring Scale VAS: Visual Analog Scale SF-36: RAND-36 (Short Form 36) IKDC: International Knee Documentation Committee IL: Interleukin TGF-: Transforming Growth Factor Beta PDGF: Platelet-Derived Growth Factor IGF: Insulin-like Growth Factor VEGF: Vascular Endothelial Growth Factor EGF: Epidermal Growth Factor -FGF: Basic Fibroblast Growth Factor NSAIDs: Non-steroidal anti-inflammatory Drugs Authors Contributions Both authors AEZ and JY equally contributed to the project

What distinguishes GHK-Cu from most research peptides is the breadth of its genomic influence

van Elburg 1993)

Differentially expressed genes, ATAC-seq peaks, TRIM28 and AP2 binding signals, and H3K27ac intensities are provided in Supplementary information, Table S6

None of the seven peptides is an FDA-approved drug, and the vote did not change that for any of them

T.WangD