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This weakens immune function and allows toxins to build up in the body, resulting in toxic overload, disease, and premature aging
Taken together, elucidating the complex interplay between ferroptosis and the TME is paramount, as the bidirectional effects of immune cells and ferroptotic cancer cells within this microenvironment can significantly modulate antitumor immunity, ultimately shaping the efficacy of PDAC therapies
Crosstalk between astrocytes and microglia: An overview
doi: 10.1016/j.chom.2009.05.002 56 HolmesD
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