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In a model of non-ischemic HF in dogs (tachycardiomyopathy induced by pacemakers), IV infusion of GLP-1 increases left ventricular (LV) contractility (LV dP/dt increased by 98%, stroke volume by 102%, and cardiac output by 57%) and decreases LV end-diastolic pressure, heart rate, and systemic vascular resistance

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Storage: Products should be stored in amber glass, ideally with a refrigerated supply chain, and maintained at a slightly acidic pH (5 to 7) for stability

This earlier study was uncontrolled, however, but justified the subsequent controlled trial

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suggested that renal tubules are not sensitized to necroptosis by loss of FADD or caspase-8, and the RIPK1 inhibitor nec-1 does not protect freshly isolated tubules from hypoxic injury, while ferroptosis directly causes synchronized necrosis of renal tubules in models of IRI-AKI [37]