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Expression of ALS-associated mutant TDP-43 A315T also leads to mitochondrial abnormalities in cell culture (Gao et al., 2019

This is termed the contact phase and can occur as a result of interaction with the phospholipids (primarily phosphatidylethanolamine, PE) of circulating lipoprotein particles such as chylomicrons, VLDLs, and oxidized LDLs

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