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TMZ sensitization Article Title : CUDC-907 inhibits glioblastoma and enhances glioblastoma sensitivity to temozolomide by inhibiting DNA damage repair References : 10.1016/j.gendis.2025.101948 Image Credits : Credit: Chencheng Fang, Pan Gou, Dandan Zhang, Xuanxuan Wu, Xiao Li, Man Li, Lu Gan, Jinjin Luo, Hongjuan Cui, Man Xu, Ping Liang Keywords : glioblastoma, CUDC-907, PI3K, HDAC, temozolomide, TMZ resistance, MYC, p21, DNA damage repair, -H2AX, PARP1, JAK-STAT, organoids, orthotopic mouse model Tags: cancer cell cycle arrestcombination therapy for resistant glioblastomaCUDC-907 mechanismdual PI3K/HDAC inhibitionGBM apoptosis inductiongene expression modulation in glioblastomaglioblastoma treatmentmolecular profiling of tumor responseovercoming chemotherapy resistancetargeted therapy in brain cancertemozolomide resistancetumor survival pathway inhibition
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Called Rybelsus, it has been FDA-approved to help treat type 2 diabetes since 2019