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Nevertheless, peptide bonds can undergo chemical reactions, usually through an attack of an electronegative atom on the carbonyl carbon, breaking the carbonyl double bond and forming a tetrahedral intermediate

For example, homocysteine (Hcy), an amino acid involved in DNA methylation, facilitates GPX4 methylation that leads to upregulation of oxidative stress and ferroptosis in nucleus pulposus (Zhang et al., 2020c)

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Patients were withdrawn if they experienced sustained elevations in blood pressure beyond predefined thresholds or significant increases from baseline [2]

The lancet Diabetes & endocrinology

A similar result was obtained when the ME1 was knocked down in the INS-1 832/13 cell line [43]