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You should consult a doctor if: The pain is severe or progressively worsening You experience burning, tingling, or numbness along with allodynia There is no identifiable cause, and symptoms persist beyond a few weeks The symptoms interfere with daily life, sleep, or mental well-being You are on GLP-1 medications and suspect a correlation with new or worsening nerve sensitivity A GP may perform neurological examinations, blood tests (to rule out deficiencies or autoimmune involvement), and imaging studies or refer you to a pain specialist or neurologist for further assessment

doi: 10.1016/j.ymthe.2024.07.027 168 CoatesTD

It is a synthetic pentadecapeptide consisting of 15 amino acid residues

In the pancreas, GLP-1 stimulates insulin secretion from beta cells in a glucose-dependent manner a crucial safety feature that reduces the risk of hypoglycaemia (dangerously low blood sugar)

As GLP-1 weight-loss drugs have moved from a niche treatment to a mainstream prescription, their impact has started showing up well beyond pharmacies

R., & Brzezinski, A