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Role of ferroptosis in PD Ferroptosis is regulated by multiple interconnected pathways, including the GPX4/GSH system, iron and lipid metabolism, the NRF2 signaling pathway and mitochondrial function, in PD (Fig
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The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]
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Diabetes Care 45 (12), 30753090
MDA is a product of lipid peroxidation and an indicator of oxidative stress, while GSH is a vital antioxidant that plays a crucial role in cellular defense mechanisms
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