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However, GLP-1 antagonists and GLP-1 agonists work differently: GLP-1 agonists (like Ozempic and Wegovy) mimic the GLP-1 hormone, activating its receptors to increase insulin release, suppress appetite, and slow digestion

Int J Mol Sci (2021) 22(4):2110

Orforglipron, Eli Lillys oral non-peptide GLP-1 agonist currently awaiting approval, is synthesized by conventional organic chemistry in a standard chemical reactor

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When you swallow an oral supplement, the active compounds have to survive stomach acid, get absorbed through the intestinal wall, and pass through the liver's first-pass metabolism before reaching systemic circulation