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25 Classic examples are -lactamases, which hydrolyze the -lactam ring of penicillins, cephalosporins, monobactams, and even carbapenems
The difference in results between local and non-local administration remains unclear from available research
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Previous reports have indicated intramolecular hydroarylation 24 , ring closure metathesis 25 , cyclo addition 26,27 , or cross coupling 28 reactions
doi: 10.1097/GRF.0000000000000637