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14 Upon application to the skin, DHA undergoes a Maillard reaction: the carbonyl group of DHA reacts with amino acids such as arginine, histidine, and lysine in the stratum corneum to produce brown-black chromophores, known as melanoidins, which provide a brown coloration (Figure 2)

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Lifestyle Changes: Diet quality, calorie intake, and exercise still play a critical role

They can develop due to acne, prolonged sun exposure, aging, or previous skin infections

Kerchenski and C

Incretin Drugs Effect on Epigenetic Machinery: New Potential Therapeutic Implications in Preventing Vascular Diabetic Complications