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The MT-II scaffold has since generated a large derivative family through substitutions at positions 6, 7 and 9, including N-methylated variants used to obtain MC1R selectivity
The amelioration of iodine-induced cytotoxicity was caused by cotreatment with antioxidant vitamin E [185]
This technique has been used successfully to treat urinary retention and urinary and fecal incontinence, and has more recently been employed to treat chronic constipation
Thus, drinking for example 2 liters of such a water plus normal diet would overload the organism with iodine dose above estimated threshold
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