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GLP-1 receptor agonists, including semaglutide, reduce alcohol intake and relapse-like behaviors in rodent and non-human primate models, and a recent clinical trial found that semaglutide decreased alcohol craving and drinking in adults with AUD
It is often prescribed for individuals with obesity, particularly when other weight loss methods have failed
46 , 216224 e212 (2022)
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The results showed a significant decrease in mean body weight, with a reduction of 12.1% compared to the placebo group
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