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In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al

Front Endocrinol (Lausanne) 12 , Liu, X., Patel, K

However, this ROS-related concept has been challenged by the proposal of cuproptosis as a novel, ROS-independent, copper-related form of RCD [54] , which plays a pathogenic role under copper overload [90]

Indeed, AOXs are extensively consumed due to their easy availability through different retail outlets ( In this review, we comprehensively discussed the types, mechanisms of action and safety profile of AOXs that are commonly prescribed in infertility clinics