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When pyocyanin is secreted inside a host, such as a CF patient, it can make its way inside the cells of the host and start to cause oxidative stress

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320 Furthermore, the induction of ZIP6 expression by STAT3 induces the translocation of ZIP6 to the plasma membrane and facilitates zinc influx, which is triggered by N-terminal cleavage

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That's why we must top it up through our diet - meat and dairy products are particularly rich in B12