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However, 6 of the 12 admitted patients were exposed to supratherapeutic doses, while 4 patients reportedly injected therapeutic doses

This subsequently activates the transmission of the downstream JAK2 signaling pathway

Based on a previous work, 30 mg/kg was considered the dose sufficient to achieve a C max comparable to the L-carnitine concentration used in vitro (1 mM) 41

The companys platform strategy includes evaluating oral, sublingual and intranasal delivery approaches that could eventually reduce reliance on injectable administration

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In contrast, in 20% TFE, SR18 displayed a significantly higher hydrodynamic diameter of 230.7 nm with a PDI of 0.4292, suggesting that SR18 may form higher-order aggregates or self-assembled structures