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Definition of hyperprogression Hyperprogression was defined using the previously established criteria for solid tumors as progressive disease in the first 8 weeks after treatment initiation, a 10 mm minimum increase in the measurable lesions, plus: (i) an increase of 40% in the sum of target lesions compared with baseline and/or (ii) an increase of 20% in the sum of the target lesions compared with baseline plus the appearance of new lesions in at least two different organs