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General guidelines and dosing for patients with T2D: Initiate pramlintide at the 60 mcg dose taken immediately prior to major meals Titrate pramlintide to 120 mcg dose after 3 or more days with no clinically significant nausea Optimize insulin to achieve glycemic targets once the maintenance dose of pramlintide is reached and blood glucose concentrations are stable Practical Tips for Patients On Pramlintide Start With a Low Dose and Titrate Slowly Pramlintide can cause nausea, anorexia and vomiting, especially in T1D where a more gradual titration is required

Basic hydration and vitamin IVs tend to be the most affordable

Acta 969 , 1825 (2017)

H2 Blockers: Which One for GLP-1 Users

It is the first injectable weight loss medication to activate two hormone pathways at once, producing greater average weight loss than any previously approved medication in its class