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Impact on NAION A paper published in 2024 in JAMA Ophthalmology created shock waves in the ophthalmic community by showing that subcutaneous semaglutide was associated with a significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy (NAION)

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123,124 If SIRS persists beyond 48 h, its specificity for poor prognosis significantly increases, and such patients should be considered for ICU transfer

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