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doi: 10.1016/j.cmet.2021.12.001
How Semaglutide & Tirzepatide Work Semaglutide (GLP-1) and Tirzepatide (GLP-1/GLP-2) mimic natural hormones in your body that regulate appetite, slow digestion, and improve satiety (the feeling of fullness)
During early protocol, MMP-9 may temporarily rise (breaking down damaged tissue)
GLP-1 receptor agonists were associated with reduced diabetic foot ulcer and lower limb amputation risk in retrospective cohort studies
The following are ways to help you manage this side effect: eating smaller meals more frequently maintaining adequate hydration taking an over-the-counter antidiarrheal medication avoiding spicy or greasy foods, which can further irritate your stomach If diarrhea becomes bothersome, talk with your doctor
Avoid skipping meals, which can cause blood sugar to swing dramatically
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