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Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies

In contrast, the GPXs are involved in the physiological adjustment of peroxide concentrations in the intracellular and extracellular compartments, and are more versatile, so they can also act as scavengers and as repair enzymes

Krug et al., 2014)

Dokl Akad Nauk SSSR

For activity screening, we adapted a GSTO1 substrate assay that relies on the quantification of the reduction of S -(4-nitrophenacyl)glutathione (4-NPG), a GSTO1-specific substrate 17 , using recombinant human GSTO1 in a high-throughput screening format

In conclusion, these results indicate a protective role of GSTP1 by increasing enzymatic detoxification of AQ-QI and DEAQ-QI and suggest a second protective mechanism by interfering with ER stress induced apoptosis