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If you are experiencing increased urination while taking a GLP-1 medication, several factors unrelated to the drug's direct mechanism may be responsible, which warrants further evaluation to identify the underlying cause

For longer use (3+ months), consider cycling

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10.1038/s41569-018-0030-z Summary Keywords D-Gal, endothelial cell senescence, FOXO4-DRI, P53, ROS Citation Hu Z, Li F, Hu C, Shan Q, Tang Z, Jiang M, Yi X, Chen X, Jin L, Wang X and Wang Y (2026) FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway