The latest SUSTAIN trial was published in 2022 that showed semaglutide once a week led to greater HBA1C reduction as compared to insulin aspart thrice per day
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Most gastrointestinal side effects with both medications occur during dose escalation and reduce significantly over time
Semaglutide and tirzepatide both reduce appetite and slow gastric emptying, but they differ in dosing, clinical weight loss averages, and side effect profiles
Table III [i] MASLD metabolic dysfunction-associated steatotic liver disease, MDA malondialdehyde, 4-HNE 4-hydroxynonenal, 8-OHdG 8-hydroxy-2-deoxyguanosine, ox-LDL oxidized low-density lipoprotein, F2-isoprostanes F2 class of prostaglandin-like compounds formed by lipid peroxidation, ELISA enzyme-linked immunosorbent assay, HPLC high-performance liquid chromatography, GC-MS gas chromatography-mass spectrometry, LC-MS/MS liquid chromatography-tandem mass spectrometry
Supplementing with BCAAs may support muscle recovery after exercise
