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635,637,638 SBI-797812 activates NAMPT via stabilizing the NAMPT phosphorylation at His247, enhancing the efficiency of NMN generation, providing another option to raise NAD +

Areloegbe, Chukwubueze L

CPP-CAND showed high selectivity and potency in inducing apoptosis in senescent cells by disrupting FOXO4-p53 foci and activating caspase pathways

Bioresour Technol 299:122633

Recent solution NMR structural investigations provide molecular models of p53 transactivation domain interactions with both FOXO4 and senolytic peptides, enabling rational design approaches for next-generation compounds

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