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After a month, the dose is gradually increased to 0.5mg for the next month

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In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, Retatrutide leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

Women aged 25-45 with BMIs between 25-28 kg/m were randomly assigned to one of two groups: [5] Supresa group: 176.5 mg of standardized saffron extract daily (split into two doses) Placebo group: Identical-looking capsules with no active ingredients A key point that differentiates this study from many weight loss trials is that participants were not placed on any caloric restrictions