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You should not take semaglutide if you are allergic to it or if you have conditions, such as: Stomach or intestinal disorder Kidney disease Pancreatitis Retinopathy (eye problems caused by diabetes) Diabetic ketoacidosis Family or personal history of thyroid cancer Multiple endocrine neoplasia type 2 (tumors in your glands) Pregnancy Side Effects of Semaglutide Semaglutide may cause side effects, such as: Diarrhea Nausea Vomiting Heartburn Burping Stomach pain Constipation Headache Low blood sugar in patients with type 2 diabetes Flatulence (gas buildup) Indigestion

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Although the number of events was small and the duration of follow-up short, patients randomised to oral semaglutide experienced a ~50% reduction in cardiovascular death (HR=0.49, 95% CI 0.27 to 0.92) and all-cause mortality (HR=0.51, 95% CI 0.31 to 0.84) (Figure 2)

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