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350 Additionally, molecular studies on lactylation should concentrate on investigating its specific effects on protein structure and the precise molecular mechanisms through which these effects are mediated, which will contribute to clarifying the orchestration of lactylation on protein function and its subsequent biological significance
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Within islet cells, GLP-1RAs activate adenylate cyclase to increase the production of intracellular cyclic adenosine monophosphate (cAMP) and to start the subsequent signaling cascade (Figure 1) [28]
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