It acts the same way as GLP-1 (a hormone produced in the gut)
Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
There was no difference when GLP-1s were compared with a third class of diabetes medications known as sodium-glucose cotransporter 2 inhibitors (SGLT2i)
(6) V Zambelli, L Rizzi, P Delvecchio, E Bresciani, et al (2021) Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury Drug Target Insights, 2021 Nov 27, Volume 15, Pages 2633
Glutathione can be found in every cell of the human body
Theyll bring you a hot pack to put on your shoulder to help with the pain