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As in many countries this is not done in clinics and as the solutions are never topical but with natural supplements, we advice that you check each solution

Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals