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Individuals with type 1 diabetes, thyroid cancer, multiple endocrine neoplasia, or end stage kidney disease at any time until cohort entry or individuals with dialysis or the latest eGFR 70 years, by males versus females, by insulin use, by atherosclerotic cardiovascular disease (i.e., myocardial infraction, angina, coronary artery disease, coronary revascularization, peripheral artery disease, aortic atherosclerotic disease, or cerebrovascular disease), by renal insufficiency (i.e., chronic kidney disease or the latest eGFR 70 years (HR [95% CI]: 0.95 [0.831.08])

Also relevant for: Anyone considering multi-ingredient collagen formulas like Elavate who wants clinically relevant doses of supporting ingredients rather than token amounts

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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

Stevens and Levin, 2013)

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