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doi: 10.3390/ANTIOX11081617 80

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Clinical trial data for semaglutide also reports musculoskeletal complaints, but again, not at rates significantly higher than placebo

Effects of GLP-1 and GIP receptor agonists include: Stimulating insulin secretion in response to food (glucose-dependent) Reducing inappropriate glucagon release, lowering hepatic glucose output (GLP-1 enhances the sensitivity of alpha cells to glucose , resulting in more glucose-appropriate glucagon secretion) When blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited