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Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study

An antagonist of LTB4 receptor, BIIL 284 inhibits the LTB4-stimulated expression of Mac-1 on neutrophils in RA patients (164)

Dietzel et al

BPC-157 is not FDA approved as a standard medication, and the FDA has identified concerns around compounded BPC-157, including possible immunogenicity risk, peptide-related impurities, and limited safety information for certain routes of administration

Both reactions can be catalysed by protein disulphide isomerase (PDI) and possibly other oxidoreductases that share common domains with PDI (for a recent review, see Ellgaard & Ruddock, 2005)