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5 Immune dysfunction in ischemic stroke and potential immunomodulatory effects of GLP-1RA 5.1 The regulatory function of immune cells in the progression of ischemic stroke The latest research shows that healthy brains do not lack immune cells

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Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]