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Further, activation of the NLRP3 cascade promotes RF through RTEC pyroptosis ( SalB enhances the nuclear accumulation of Nrf2 and suppresses NLRP3 activation, oxidative stress, and Caspase-1/Gasdermin D-mediated cellular pyroptosis via the Nrf2/NLRP3 pathway (Pang et al., 2020)

Pearsons correlation coefficient was calculated to assess the strength of association between qRT-PCR and RNA-sequencing data

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Bridging the gap between findings in animal models and human applications is a critical step toward achieving clinical success

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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise