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NPJ Digit Med
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This suggests the presence of compensatory mechanisms involving other hypothalamic or extra-hypothalamic regions [80,93]
Tirzepatide is a biased agonist favouring cAMP production over -arrestin recruitment, which may reduce receptor internalisation and potentially enhance GLP-1 signalling [70] GLP-1 and control of gastric emptying: normal physiology and diabetes GLP-1 inhibits gastrointestinal motility and gastric secretion (Fig
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