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Polyphenols like resveratrol and epigallocatechin gallate have been shown to offer protection against nephrotoxicity caused by toxins, ischemia, and metabolic diseases (Baptista et al
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It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges
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IGF-I Lr3 is significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins
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