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this observation suggests that inactivation of the GPx3 gene by hypermethylation of the promoter may contribute to breast cancer progression

In the Methods, we explain why we take the multiplier, S , of the V max values of GCL and GPX to have the following dependence on estradiol, E 2: Thus, since male E 2 is 0.09 nM [26] , S = 1 for the male

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