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Int J Oncol 40:10491057 Zhen Y-Z, Lin Y-J, Gao J-L et al (2011) Rhein lysinate inhibits cell growth by modulating various mitogen-activated protein kinases in cervical cancer cells
Eur J Endocrinol 1998
Photoprotective DNA Repair Signaling Research demonstrates that MC1R activation by -MSH analogues including MT-1 upregulates nucleotide excision repair (NER) capacity in melanocytes, reducing UV-induced cyclobutane pyrimidine dimer (CPD) accumulation independently of melanin pigmentation (Kadekaro et al., Cancer Research, 2005)
Studies in mice found potent antinociceptive (pain-reducing) effects when the peptide was administered directly to the central nervous system
The mechanism involves potentially supporting natural GLP-1 production indirectly through gut health improvements, which produces effects within normal physiological ranges
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